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Natural Conversations

Natural Conversations

Chat with your research papers in plain English. Ask questions and get precise answers with exact citations.

Ask questions in natural language
Get precise answers with citations
No more endless PDF scrolling
Understand complex concepts quickly
Natural Conversations

100+ Languages

Research in any language. German papers, Chinese studies - we handle them all seamlessly.

Lightning Fast

Process 20,000-page documents in seconds. No waiting, no delays, just instant insights.

Secure & Private

Enterprise-grade security with end-to-end encryption. Your research stays confidential.

Team Collaboration

Share insights with your team. Collaborate on research projects in real-time.

Perfect Citations

Generate flawless citations in any format. APA, MLA, Chicago - all handled automatically.

Document Analysis

Upload any document format. PDFs, Word docs, PowerPoints - we analyze them all.

Research madeeffortless

Four simple steps to transform how you work with research papers

Step 1 of 4

Instant Paper Analysis

Upload and understand any research paper in seconds

Support for PDF, DOCX, and more
Automatic text extraction
Smart content parsing
Preserve formatting and structure

Upload Paper

Drop any research paper, textbook, or document

Smart Flashcards

Master any subject with AI-generated flashcards

Transform research papers into comprehensive study materials with intelligent spaced repetition

Question 1 of 3

What are the primary mechanisms of action for ACE inhibitors in treating hypertension?

Click to reveal answer

Auto-Generated

AI creates flashcards from any research paper or document you upload

Spaced Repetition

Smart scheduling shows cards when you need to review them most

Source Citations

Every flashcard links back to the original research paper

Master clinical scenarios with neural voice synthesis

Practice realistic patient interactions powered by Sesame's Conversational Speech Model—advanced transformer architecture that generates contextually-aware, emotionally intelligent speech for clinical training

The Limitations of Traditional Clinical Assessment

Current State

Traditional OSCE assessments rely on standardized patients (SPs) with inherent limitations: limited demographic diversity, scripted responses, inconsistent performance across examinations, and prohibitive costs for frequent practice sessions.

Medical students typically receive fewer than 20 hours of SP interaction before high-stakes clinical exams, with minimal exposure to diverse communication styles, accents, emotional states, or rare clinical presentations.

The Innovation Gap

Previous AI patient simulators have struggled with the "uncanny valley" effect—synthetic voices that sound robotic, lack emotional depth, and fail to respond naturally to conversational cues. This undermines learning effectiveness and fails to prepare students for real clinical interactions.

The challenge: creating AI patients that cross the uncanny valley with natural prosody, emotional intelligence, and contextual awareness indistinguishable from human communication.

Sesame Conversational Speech Model: Technical Architecture

Transformer-Based Architecture

Sesame's CSM uses a novel transformer architecture optimized for conversational speech generation. Unlike traditional TTS systems that operate on isolated utterances, CSM maintains conversational context across multi-turn dialogues, enabling natural flow and coherent responses.

The model employs a hierarchical attention mechanism that captures both local (phoneme-level) and global (discourse-level) features, allowing for contextually appropriate prosody, timing, and emotional expression.

  • 24-layer transformer with 512M parameters optimized for speech synthesis
  • Multi-head attention mechanisms for prosodic feature extraction
  • Contextual embedding layer for emotional state tracking
  • Adversarial training for natural speech rhythm and timing

Amortized Training & Inference

The CSM uses an amortized inference approach that dramatically reduces latency while maintaining high-fidelity output. Traditional diffusion-based speech models require hundreds of denoising steps; Sesame's approach achieves comparable quality in a single forward pass.

This breakthrough enables real-time conversational AI with latency under 200ms—critical for natural clinical dialogue where delayed responses break immersion and reduce training effectiveness.

  • Single-step inference with 180ms average latency
  • Consistency distillation for quality-preserving compression
  • GPU-optimized inference pipeline for scalability
  • Dynamic batching for efficient resource utilization
Conversational Speech Model Architecture

Figure 1: CSM Architecture with hierarchical attention and prosodic feature extraction

Amortized Training Process

Figure 2: Amortized training pipeline with consistency distillation

Paralinguistic Modeling

Advanced prosodic feature extraction captures subtle emotional cues: pitch modulation, speech rate variation, pause duration, and voice quality changes that convey patient emotional state.

Contextual Awareness

The model maintains dialogue state across turns, adapting emotional expression and communication style based on conversational context, clinical urgency, and patient history.

Multilingual Support

Native pronunciation of medical terminology and foreign words across 40+ languages, enabling diverse patient demographic simulation without acoustic artifacts.

Technical Specifications

Model Parameters512M (encoder) + 180M (decoder)
Audio Quality48kHz, 24-bit depth
Inference Latency180ms (p50), 240ms (p99)
Training Data450k hours conversational speech
Context Window32 conversational turns
Emotional States23 distinct emotional categories
Language Support42 languages + medical terminology
Naturalness Score (MOS)4.6/5.0 (human parity: 4.7)

Clinical Voice Technology Demonstrations

These samples demonstrate the three critical dimensions of conversational speech synthesis: paralinguistic expression, accurate pronunciation of complex terminology, and contextual emotional adaptation.

Paralinguistics

Emotional expression and non-verbal communication captured through prosodic features

Patient expressing pain

00:07

Empathetic response

00:03

Foreign Words & Terminology

Accurate pronunciation of medical terminology and multilingual patient names

Complex medical terminology

00:09

International patient names

00:06

Contextual Expressivity

Dynamic emotional adaptation based on clinical context and patient state

Breaking difficult news

00:22

Reassuring anxious patient

00:22

"Voice is our most intimate medium as humans, carrying layers of meaning through countless variations in tone, pitch, rhythm, and emotion. Creating truly conversational AI requires modeling not just what is said, but how it's said—the prosodic features that make speech feel human."
— Sesame Research Team

Realistic Patient Interactions

Practice with AI patients powered by neural voice synthesis that responds naturally to clinical communication

Immediate Detailed Feedback

Receive instant AI-powered assessment of clinical reasoning, communication skills, and diagnostic approach

Comprehensive Clinical Coverage

Access evidence-based scenarios across all medical specialties with graduated difficulty levels

Clinical Excellence

Master OSCE Assessments

Experience our comprehensive OSCE training platform with real-time vital signs monitoring, task tracking, and performance analytics.

Serenoty Labs OSCE Training Platform

OSCE Training Platform

Advanced clinical assessment and performance monitoring

Total Cases

24

Completed

18

Average Score

87%

Study Hours

32.5h

Available Cases

Sarah Johnson

Cardiology

Advanced

Chest pain with radiating discomfort

15 min

Michael Chen

Emergency

Intermediate

Acute respiratory distress

15 min

Emma Williams

Internal Medicine

Beginner

Persistent fever and fatigue

15 min

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